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Liposomal Tetrahydrobiopterin Preserves eNOS Coupling in the Post-ischemic Heart Conferring in vivo Cardioprotection

Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthase (NOS), and reduced BH(4) availability leads to endothelial NOS (eNOS) uncoupling and increased reactive oxygen species (ROS) generation. Questions remain regarding the functional state of eNOS and role of BH(4) availabilit...

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Détails bibliographiques
Publié dans:J Mol Cell Cardiol
Auteurs principaux: Xie, Lin, Talukder, M A Hassan, Sun, Jian, Varadharaj, Saradhadevi, Zweier, Jay L.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558339/
https://ncbi.nlm.nih.gov/pubmed/26116866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.015
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