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Liposomal Tetrahydrobiopterin Preserves eNOS Coupling in the Post-ischemic Heart Conferring in vivo Cardioprotection

Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthase (NOS), and reduced BH(4) availability leads to endothelial NOS (eNOS) uncoupling and increased reactive oxygen species (ROS) generation. Questions remain regarding the functional state of eNOS and role of BH(4) availabilit...

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Bibliografiske detaljer
Udgivet i:J Mol Cell Cardiol
Main Authors: Xie, Lin, Talukder, M A Hassan, Sun, Jian, Varadharaj, Saradhadevi, Zweier, Jay L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558339/
https://ncbi.nlm.nih.gov/pubmed/26116866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.015
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