Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms

Localized exogenous R-tetrahydrobiopterin (R-BH(4)) corrects the deficit in local heat-induced vasodilation (VD) in hypercholesterolemic (HC) human skin through one of two plausible mechanisms: by serving as an essential cofactor to stabilizing endothelial nitric oxide (NO) synthase (eNOS) or throug...

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Main Authors: Alexander, Lacy M., Kutz, Jessica L., Kenney, W. Larry
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Cardiovascular and Renal Integration
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543657/
https://ncbi.nlm.nih.gov/pubmed/23193114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00448.2012
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