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Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABA(A) Receptors
Propofol is a sedative and anesthetic agent that can both activate GABA(A) receptors and potentiate receptor activation elicited by submaximal concentrations of the transmitter. A recent modeling study of the β3 homomeric GABA(A) receptor postulated a high-affinity propofol binding site in a hydroph...
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| Publicado no: | Mol Pharmacol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576687/ https://ncbi.nlm.nih.gov/pubmed/26206487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.100347 |
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