Mechanistic Analysis of Ghrelin-O-Acyltransferase Using Substrate Analogs

Ghrelin-O-Acyltransferase (GOAT) is an 11-transmembrane integral membrane protein that octanoylates the metabolism-regulating peptide hormone ghrelin at Ser3 and may represent an attractive target for the treatment of type II diabetes and the metabolic syndrome. Protein octanoylation is unique to gh...

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Udgivet i:Bioorg Chem
Main Authors: Taylor, Martin S., Dempsey, Daniel R., Hwang, Yousang, Chen, Zan, Chu, Nam, Boeke, Jef D., Cole, Philip A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567917/
https://ncbi.nlm.nih.gov/pubmed/26246082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2015.07.003
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