Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The biological activities of ghrelin require octanoylation of the peptide on Ser3, an unusual post-translational modification that is catalyzed by the enzyme ghrelin O-acyltransferase (GOAT). Here, we describe the desig...

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Main Authors: Barnett, Brad P., Hwang, Yousang, Taylor, Martin S., Kirchner, Henriette, Pfluger, Paul T., Bernard, Vincent, Lin, Yu-yi, Bowers, Erin M., Mukherjee, Chandrani, Song, Woo-Jin, Longo, Patti A., Leahy, Daniel J., Hussain, Mehboob A., Tschöp, Matthias H., Boeke, Jef D., Cole, Philip A.
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068526/
https://ncbi.nlm.nih.gov/pubmed/21097901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1196154
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