Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography

[Image: see text] The adenosine triphosphate-binding cassette transporter P-glycoprotein (ABCB1/Abcb1a) restricts at the blood–brain barrier (BBB) brain distribution of many drugs. ABCB1 may be involved in drug–drug interactions (DDIs) at the BBB, which may lead to changes in brain distribution and...

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Bibliografske podrobnosti
izdano v:Mol Pharm
Main Authors: Wanek, Thomas, Römermann, Kerstin, Mairinger, Severin, Stanek, Johann, Sauberer, Michael, Filip, Thomas, Traxl, Alexander, Kuntner, Claudia, Pahnke, Jens, Bauer, Florian, Erker, Thomas, Löscher, Wolfgang, Müller, Markus, Langer, Oliver
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566129/
https://ncbi.nlm.nih.gov/pubmed/26202880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00168
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