The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: a positron emission tomography study

Aim of this study was to determine whether the carbon-11-labelled antiepileptic drug [(11)C]mephobarbital is a substrate of P-glycoprotein (Pgp) and can be used to assess Pgp function at the blood-brain barrier (BBB) with positron emission tomography (PET). We performed paired PET scans in rats, wil...

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Main Authors: Mairinger, Severin, Bankstahl, Jens P., Kuntner, Claudia, Römermann, Kerstin, Bankstahl, Marion, Wanek, Thomas, Stanek, Johann, Löscher, Wolfgang, Müller, Markus, Erker, Thomas, Langer, Oliver
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778256/
https://ncbi.nlm.nih.gov/pubmed/22342565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2012.01.012
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