A comparative small-animal PET evaluation of [(11)C]tariquidar, [(11)C]elacridar and (R)-[(11)C]verapamil for detection of P-glycoprotein expressing murine breast cancer

PURPOSE: One important mechanism for chemoresistance of tumours is overexpression of the adenosine triphosphate-binding cassette transporter P-glycoprotein (Pgp). Pgp reduces intracellular concentrations of chemotherapeutic drugs. Aim of this study was to compare the suitability of the radiolabelled...

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Main Authors: Wanek, Thomas, Kuntner, Claudia, Bankstahl, Jens P., Bankstahl, Marion, Stanek, Johann, Sauberer, Michael, Mairinger, Severin, Strommer, Sabine, Wacheck, Volker, Löscher, Wolfgang, Erker, Thomas, Müller, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684861/
https://ncbi.nlm.nih.gov/pubmed/21983837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-011-1941-7
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