Synthesis and in vivo evaluation of [(11)C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

The aim of this study was to develop a positron emission tomography (PET) tracer based on the dual P-glycoprotein (P-gp) breast cancer resistance protein (BCRP) inhibitor tariquidar (1) to study the interaction of 1 with P-gp and BCRP in the blood-brain barrier (BBB) in vivo. O-desmethyl-1 was synth...

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Main Authors: Bauer, Florian, Kuntner, Claudia, Bankstahl, Jens P., Wanek, Thomas, Bankstahl, Marion, Stanek, Johann, Mairinger, Severin, Dörner, Bernd, Löscher, Wolfgang, Müller, Markus, Erker, Thomas, Langer, Oliver
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690440/
https://ncbi.nlm.nih.gov/pubmed/20621487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.057
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