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Synthesis and in vivo evaluation of [(11)C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor
The aim of this study was to develop a positron emission tomography (PET) tracer based on the dual P-glycoprotein (P-gp) breast cancer resistance protein (BCRP) inhibitor tariquidar (1) to study the interaction of 1 with P-gp and BCRP in the blood-brain barrier (BBB) in vivo. O-desmethyl-1 was synth...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690440/ https://ncbi.nlm.nih.gov/pubmed/20621487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.057 |
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