Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography

HM30181, a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (Pgp), was shown to enhance oral bioavailability and improve antitumour efficacy of paclitaxel in mouse tumour models. In search for a positron emission tomography (PET) radiotracer to...

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Main Authors: Bauer, Florian, Wanek, Thomas, Mairinger, Severin, Stanek, Johann, Sauberer, Michael, Kuntner, Claudia, Parveen, Zahida, Chiba, Peter, Müller, Markus, Langer, Oliver, Erker, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690544/
https://ncbi.nlm.nih.gov/pubmed/23022332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.09.013
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