Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography

[Image: see text] The adenosine triphosphate-binding cassette transporter P-glycoprotein (ABCB1/Abcb1a) restricts at the blood–brain barrier (BBB) brain distribution of many drugs. ABCB1 may be involved in drug–drug interactions (DDIs) at the BBB, which may lead to changes in brain distribution and...

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Publicado en:Mol Pharm
Main Authors: Wanek, Thomas, Römermann, Kerstin, Mairinger, Severin, Stanek, Johann, Sauberer, Michael, Filip, Thomas, Traxl, Alexander, Kuntner, Claudia, Pahnke, Jens, Bauer, Florian, Erker, Thomas, Löscher, Wolfgang, Müller, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566129/
https://ncbi.nlm.nih.gov/pubmed/26202880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00168
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