Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET

PURPOSE: Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to central nervous system drug treatment. (R)-[(11)C]verapamil (VPM) PET can be used to measure the function of P-gp at the BBB, but lo...

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Autores principales: Kuntner, Claudia, Bankstahl, Jens P., Bankstahl, Marion, Stanek, Johann, Wanek, Thomas, Stundner, Gloria, Karch, Rudolf, Brauner, Rebecca, Meier, Martin, Ding, Xiaoqi, Müller, Markus, Löscher, Wolfgang, Langer, Oliver
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690672/
https://ncbi.nlm.nih.gov/pubmed/20016890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-009-1332-5
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