PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties

Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer cells. Recently, higher quantities of phosphatidylethanolamine (PE) were also found at these cells’ surface. We...

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Publicat a:Biophys J
Autors principals: Leite, Natália Bueno, Aufderhorst-Roberts, Anders, Palma, Mario Sergio, Connell, Simon D., Neto, João Ruggiero, Beales, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2015
Matèries:
Membranes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564682/
https://ncbi.nlm.nih.gov/pubmed/26331251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.033
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