PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties

Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer cells. Recently, higher quantities of phosphatidylethanolamine (PE) were also found at these cells’ surface. We...

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Dettagli Bibliografici
Pubblicato in:Biophys J
Autori principali: Leite, Natália Bueno, Aufderhorst-Roberts, Anders, Palma, Mario Sergio, Connell, Simon D., Neto, João Ruggiero, Beales, Paul A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2015
Soggetti:
Membranes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564682/
https://ncbi.nlm.nih.gov/pubmed/26331251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.033
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