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PH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides

pH-triggered membrane permeabilizing peptides could be exploited in a variety of applications, such as to enable cargo release from endosomes for cellular delivery, or as cancer therapeutics that selectively permeabilize the plasma membranes of malignant cells. Such peptides would be especially usef...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Wiedman, Gregory, Kim, Sarah Y., Zapata-Mercado, Elmer, Wimley, William C., Hristova, Kalina
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521809/
https://ncbi.nlm.nih.gov/pubmed/28001058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11447
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