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Testing the limits of rational design by engineering pH sensitivity into membrane active peptides

In this work, we sought to rationally design membrane active peptides that are triggered by low pH to form macromolecular-sized pores in lipid bilayers. Such peptides could have broad utility in biotechnology and in nanomedicine as cancer therapeutics or drug delivery vehicles that promote release o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta
Prif Awduron: Wiedman, Gregory, Wimley, William C., Hristova, Kalina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331263/
https://ncbi.nlm.nih.gov/pubmed/25572997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.12.023
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