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Testing the limits of rational design by engineering pH sensitivity into membrane active peptides
In this work, we sought to rationally design membrane active peptides that are triggered by low pH to form macromolecular-sized pores in lipid bilayers. Such peptides could have broad utility in biotechnology and in nanomedicine as cancer therapeutics or drug delivery vehicles that promote release o...
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| Publicado en: | Biochim Biophys Acta |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331263/ https://ncbi.nlm.nih.gov/pubmed/25572997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.12.023 |
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