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Testing the limits of rational design by engineering pH sensitivity into membrane active peptides

In this work, we sought to rationally design membrane active peptides that are triggered by low pH to form macromolecular-sized pores in lipid bilayers. Such peptides could have broad utility in biotechnology and in nanomedicine as cancer therapeutics or drug delivery vehicles that promote release o...

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Bibliografiska uppgifter
I publikationen:Biochim Biophys Acta
Huvudupphovsmän: Wiedman, Gregory, Wimley, William C., Hristova, Kalina
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331263/
https://ncbi.nlm.nih.gov/pubmed/25572997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.12.023
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