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PH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides

pH-triggered membrane permeabilizing peptides could be exploited in a variety of applications, such as to enable cargo release from endosomes for cellular delivery, or as cancer therapeutics that selectively permeabilize the plasma membranes of malignant cells. Such peptides would be especially usef...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Wiedman, Gregory, Kim, Sarah Y., Zapata-Mercado, Elmer, Wimley, William C., Hristova, Kalina
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521809/
https://ncbi.nlm.nih.gov/pubmed/28001058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11447
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