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PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties

Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer cells. Recently, higher quantities of phosphatidylethanolamine (PE) were also found at these cells’ surface. We...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Leite, Natália Bueno, Aufderhorst-Roberts, Anders, Palma, Mario Sergio, Connell, Simon D., Neto, João Ruggiero, Beales, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564682/
https://ncbi.nlm.nih.gov/pubmed/26331251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.033
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