An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

BACKGROUND: Senile plaques consisting of amyloid-beta (Aβ) are the major pathological hallmark of Alzheimer’s disease (AD) and have been the primary therapeutic target. Immunotherapies, which are designed to remove brain Aβ deposits, increased levels of soluble Aβ and accelerated brain atrophy in so...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Liu, Yu-Hui, Bu, Xian-Le, Liang, Chun-Rong, Wang, Ye-Ran, Zhang, Tao, Jiao, Shu-Sheng, Zeng, Fan, Yao, Xiu-Qing, Zhou, Hua-Dong, Deng, Juan, Wang, Yan-Jiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551765/
https://ncbi.nlm.nih.gov/pubmed/26311039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0379-4
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