An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

BACKGROUND: Senile plaques consisting of amyloid-beta (Aβ) are the major pathological hallmark of Alzheimer’s disease (AD) and have been the primary therapeutic target. Immunotherapies, which are designed to remove brain Aβ deposits, increased levels of soluble Aβ and accelerated brain atrophy in so...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Liu, Yu-Hui, Bu, Xian-Le, Liang, Chun-Rong, Wang, Ye-Ran, Zhang, Tao, Jiao, Shu-Sheng, Zeng, Fan, Yao, Xiu-Qing, Zhou, Hua-Dong, Deng, Juan, Wang, Yan-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551765/
https://ncbi.nlm.nih.gov/pubmed/26311039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0379-4
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