Nalaganje...
An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect
BACKGROUND: Senile plaques consisting of amyloid-beta (Aβ) are the major pathological hallmark of Alzheimer’s disease (AD) and have been the primary therapeutic target. Immunotherapies, which are designed to remove brain Aβ deposits, increased levels of soluble Aβ and accelerated brain atrophy in so...
Shranjeno v:
| izdano v: | J Neuroinflammation |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551765/ https://ncbi.nlm.nih.gov/pubmed/26311039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0379-4 |
| Oznake: |
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