Visualizing Transient Watson-Crick Like Mispairs in DNA and RNA Duplexes

Rare tautomeric and anionic nucleobases are believed to play fundamental biological roles but their prevalence and functional importance has remained elusive because they exist transiently, in low-abundance, and involve subtle movements of protons that are difficult to visualize. Using NMR relaxatio...

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Pubblicato in:Nature
Autori principali: Kimsey, Isaac J., Petzold, Katja, Sathyamoorthy, Bharathwaj, Stein, Zachary W., Al-Hashimi, Hashim M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547696/
https://ncbi.nlm.nih.gov/pubmed/25762137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14227
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