Insights into Watson–Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m(1)A

In the canonical DNA double helix, Watson–Crick (WC) base pairs (bps) exist in dynamic equilibrium with sparsely populated (∼0.02–0.4%) and short-lived (lifetimes ∼0.2–2.5 ms) Hoogsteen (HG) bps. To gain insights into transient HG bps, we used solution-state nuclear magnetic resonance spectroscopy,...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Sathyamoorthy, Bharathwaj, Shi, Honglue, Zhou, Huiqing, Xue, Yi, Rangadurai, Atul, Merriman, Dawn K., Al-Hashimi, Hashim M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435913/
https://ncbi.nlm.nih.gov/pubmed/28369571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx186
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