Insights into Watson–Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m(1)A

In the canonical DNA double helix, Watson–Crick (WC) base pairs (bps) exist in dynamic equilibrium with sparsely populated (∼0.02–0.4%) and short-lived (lifetimes ∼0.2–2.5 ms) Hoogsteen (HG) bps. To gain insights into transient HG bps, we used solution-state nuclear magnetic resonance spectroscopy,...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Sathyamoorthy, Bharathwaj, Shi, Honglue, Zhou, Huiqing, Xue, Yi, Rangadurai, Atul, Merriman, Dawn K., Al-Hashimi, Hashim M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435913/
https://ncbi.nlm.nih.gov/pubmed/28369571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx186
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