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Insights into Watson–Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m(1)A

In the canonical DNA double helix, Watson–Crick (WC) base pairs (bps) exist in dynamic equilibrium with sparsely populated (∼0.02–0.4%) and short-lived (lifetimes ∼0.2–2.5 ms) Hoogsteen (HG) bps. To gain insights into transient HG bps, we used solution-state nuclear magnetic resonance spectroscopy,...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Sathyamoorthy, Bharathwaj, Shi, Honglue, Zhou, Huiqing, Xue, Yi, Rangadurai, Atul, Merriman, Dawn K., Al-Hashimi, Hashim M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435913/
https://ncbi.nlm.nih.gov/pubmed/28369571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx186
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