Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?

A(syn)-U/T and G(syn)-C(+) Hoogsteen (HG) base pairs (bps) are energetically more disfavored relative to Watson–Crick (WC) bps in A-RNA as compared to B-DNA by >1 kcal/mol for reasons that are not fully understood. Here, we used NMR spectroscopy, optical melting experiments, molecular dynamics si...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Rangadurai, Atul, Zhou, Huiqing, Merriman, Dawn K, Meiser, Nathalie, Liu, Bei, Shi, Honglue, Szymanski, Eric S, Al-Hashimi, Hashim M
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237737/
https://ncbi.nlm.nih.gov/pubmed/30285154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky885
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