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Atomic Structures of Excited State A-T Hoogsteen Base Pairs in Duplex DNA by Combining NMR Relaxation Dispersion, Mutagenesis, and Chemical Shift Calculations
NMR relaxation dispersion studies indicate that in canonical duplex DNA, Watson-Crick base pairs (bps) exist in dynamic equilibrium with short-lived low abundance excited state Hoogsteen bps. N1-methylated adenine (m(1)A) and guanine (m(1)G) are naturally occurring forms of damage that stabilize Hoo...
Shranjeno v:
| izdano v: | J Biomol NMR |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6048961/ https://ncbi.nlm.nih.gov/pubmed/29675775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-018-0177-2 |
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