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Atomic Structures of Excited State A-T Hoogsteen Base Pairs in Duplex DNA by Combining NMR Relaxation Dispersion, Mutagenesis, and Chemical Shift Calculations

NMR relaxation dispersion studies indicate that in canonical duplex DNA, Watson-Crick base pairs (bps) exist in dynamic equilibrium with short-lived low abundance excited state Hoogsteen bps. N1-methylated adenine (m(1)A) and guanine (m(1)G) are naturally occurring forms of damage that stabilize Hoo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biomol NMR
Prif Awduron: Shi, Honglue, Clay, Mary C., Rangadurai, Atul, Sathyamoorthy, Bharathwaj, Case, David A., Al-Hashimi, Hashim M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048961/
https://ncbi.nlm.nih.gov/pubmed/29675775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-018-0177-2
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