Atomic Structures of Excited State A-T Hoogsteen Base Pairs in Duplex DNA by Combining NMR Relaxation Dispersion, Mutagenesis, and Chemical Shift Calculations

NMR relaxation dispersion studies indicate that in canonical duplex DNA, Watson-Crick base pairs (bps) exist in dynamic equilibrium with short-lived low abundance excited state Hoogsteen bps. N1-methylated adenine (m(1)A) and guanine (m(1)G) are naturally occurring forms of damage that stabilize Hoo...

Full description

Saved in:
Bibliographic Details
Published in:J Biomol NMR
Main Authors: Shi, Honglue, Clay, Mary C., Rangadurai, Atul, Sathyamoorthy, Bharathwaj, Case, David A., Al-Hashimi, Hashim M.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048961/
https://ncbi.nlm.nih.gov/pubmed/29675775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-018-0177-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items