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Probing Transient Hoogsteen Hydrogen Bonds in Canonical Duplex DNA Using NMR Relaxation Dispersion and Single-atom Substitution

Nucleic acids transiently morph into alternative conformations that can be difficult to characterize at the atomic level by conventional methods because they exist for too little time and in too little abundance. We recently reported evidence for transient Hoogsteen base pairs in canonical B-DNA bas...

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Detalhes bibliográficos
Main Authors: Nikolova, Evgenia N., Gottardo, Federico L., Al-Hashimi, Hashim M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791138/
https://ncbi.nlm.nih.gov/pubmed/22309937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2117816
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