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Guanine to Inosine Substitution Leads to Large Increases in the Population of a Transient G·C Hoogsteen Base Pair
[Image: see text] We recently showed that Watson–Crick base pairs in canonical duplex DNA exist in dynamic equilibrium with G(syn)·C(+) and A(syn)·T Hoogsteen base pairs that have minute populations of ∼1%. Here, using nuclear magnetic resonance R(1ρ) relaxation dispersion, we show that substitution...
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| Publicat a: | Biochemistry |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American
Chemical Society
2014
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4245982/ https://ncbi.nlm.nih.gov/pubmed/25339065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5011909 |
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