Guanine to Inosine Substitution Leads to Large Increases in the Population of a Transient G·C Hoogsteen Base Pair

[Image: see text] We recently showed that Watson–Crick base pairs in canonical duplex DNA exist in dynamic equilibrium with G(syn)·C(+) and A(syn)·T Hoogsteen base pairs that have minute populations of ∼1%. Here, using nuclear magnetic resonance R(1ρ) relaxation dispersion, we show that substitution...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Nikolova, Evgenia N., Stull, Frederick, Al-Hashimi, Hashim M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245982/
https://ncbi.nlm.nih.gov/pubmed/25339065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5011909
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