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Characterizing the Protonation State of Cytosine in Transient G•C Hoogsteen Base Pairs in Duplex DNA

G•C Hoogsteen base pairs can form transiently in duplex DNA and play important roles in DNA recognition, replication and repair. G•C Hoogsteen base pairs are thought to be stabilized by protonation of cytosine N3, which affords a second key hydrogen bond, but experimental evidence for this is sparse...

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Detalhes bibliográficos
Main Authors: Nikolova, Evgenia N., Goh, Garrett B., Brooks, Charles L., Al-Hashimi, Hashim M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713198/
https://ncbi.nlm.nih.gov/pubmed/23506098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400994e
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