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Visualizing Transient Watson-Crick Like Mispairs in DNA and RNA Duplexes

Rare tautomeric and anionic nucleobases are believed to play fundamental biological roles but their prevalence and functional importance has remained elusive because they exist transiently, in low-abundance, and involve subtle movements of protons that are difficult to visualize. Using NMR relaxatio...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Kimsey, Isaac J., Petzold, Katja, Sathyamoorthy, Bharathwaj, Stein, Zachary W., Al-Hashimi, Hashim M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547696/
https://ncbi.nlm.nih.gov/pubmed/25762137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14227
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