Visualizing Transient Watson-Crick Like Mispairs in DNA and RNA Duplexes

Rare tautomeric and anionic nucleobases are believed to play fundamental biological roles but their prevalence and functional importance has remained elusive because they exist transiently, in low-abundance, and involve subtle movements of protons that are difficult to visualize. Using NMR relaxatio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Kimsey, Isaac J., Petzold, Katja, Sathyamoorthy, Bharathwaj, Stein, Zachary W., Al-Hashimi, Hashim M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547696/
https://ncbi.nlm.nih.gov/pubmed/25762137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14227
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