Probing conformational transitions towards mutagenic Watson–Crick-like G·T mismatches using off-resonance sugar carbon R(1ρ) relaxation dispersion

NMR off-resonance R(1ρ) relaxation dispersion measurements on base carbon and nitrogen nuclei have revealed that wobble G·T/U mismatches in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-abundance, and mutagenic Watson–Crick-like conformations. As Watson–Crick-like G·T misma...

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Bibliographic Details
Published in:J Biomol NMR
Main Authors: Rangadurai, Atul, Szymanski, Eric S., Kimsey, Isaac, Shi, Honglue, Al-Hashimi, Hashim M.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508749/
https://ncbi.nlm.nih.gov/pubmed/32789613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-020-00337-7
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