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Probing conformational transitions towards mutagenic Watson–Crick-like G·T mismatches using off-resonance sugar carbon R(1ρ) relaxation dispersion
NMR off-resonance R(1ρ) relaxation dispersion measurements on base carbon and nitrogen nuclei have revealed that wobble G·T/U mismatches in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-abundance, and mutagenic Watson–Crick-like conformations. As Watson–Crick-like G·T misma...
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| Publicado en: | J Biomol NMR |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer Netherlands
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7508749/ https://ncbi.nlm.nih.gov/pubmed/32789613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-020-00337-7 |
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