Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active s...

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Pubblicato in:PLoS Genet
Autori principali: Marada, Suresh, Navarro, Gemma, Truong, Ashley, Stewart, Daniel P., Arensdorf, Angela M., Nachtergaele, Sigrid, Angelats, Edgar, Opferman, Joseph T., Rohatgi, Rajat, McCormick, Peter J., Ogden, Stacey K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546403/
https://ncbi.nlm.nih.gov/pubmed/26291458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005473
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