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The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation
The Hedgehog (Hh) signaling pathway plays an instructional role during development, and is frequently activated in cancer. Ligand-induced pathway activation requires signaling by the transmembrane protein Smoothened (Smo), a member of the G-protein-coupled receptor (GPCR) superfamily. The extracellu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252357/ https://ncbi.nlm.nih.gov/pubmed/22223683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.075614 |
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