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The Unfolded Protein Response Selectively Targets Active Smoothened Mutants

The Hedgehog signaling pathway, an essential regulator of developmental patterning, has been implicated in playing causative and survival roles in a range of human cancers. The signal-transducing component of the pathway, Smoothened, has revealed itself to be an efficacious therapeutic target in com...

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Detalhes bibliográficos
Main Authors: Marada, Suresh, Stewart, Daniel P., Bodeen, William J., Han, Young-Goo, Ogden, Stacey K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700102/
https://ncbi.nlm.nih.gov/pubmed/23572559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01445-12
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