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The Unfolded Protein Response Selectively Targets Active Smoothened Mutants
The Hedgehog signaling pathway, an essential regulator of developmental patterning, has been implicated in playing causative and survival roles in a range of human cancers. The signal-transducing component of the pathway, Smoothened, has revealed itself to be an efficacious therapeutic target in com...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700102/ https://ncbi.nlm.nih.gov/pubmed/23572559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01445-12 |
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