Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active s...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Marada, Suresh, Navarro, Gemma, Truong, Ashley, Stewart, Daniel P., Arensdorf, Angela M., Nachtergaele, Sigrid, Angelats, Edgar, Opferman, Joseph T., Rohatgi, Rajat, McCormick, Peter J., Ogden, Stacey K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546403/
https://ncbi.nlm.nih.gov/pubmed/26291458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005473
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