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The bioactive Taxol conformation on β-tubulin: Experimental evidence from highly active constrained analogs
The important anticancer drug Taxol (paclitaxel) binds to tubulin in a stoichiometric ratio and promotes its assembly into microtubules. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been made. In this work we present experimental and...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC454156/ https://ncbi.nlm.nih.gov/pubmed/15226503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403459101 |
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