Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology and SAR Studies of C-4 to C-3′ Bridged Paclitaxel Analogs

The important anticancer drug paclitaxel binds to the β-subunit of the αβ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have bee...

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Bibliografiske detaljer
Main Authors:	Ganesh, Thota, Yang, Chao, Norris, Andrew, Glass, Tom, Bane, Susan, Ravindra, Rudravajhala, Banerjee, Abhijit, Metaferia, Belhu, Thomas, Shala L., Giannakakou, Paraskevi, Alcaraz, Ana A., Lakdawala, Ami S., Snyder, James P., Kingston, David G. I.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2007
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2585518/ https://ncbi.nlm.nih.gov/pubmed/17263521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061071x
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Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology and SAR Studies of C-4 to C-3′ Bridged Paclitaxel Analogs

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