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Promotion of Tubulin Assembly by Poorly Soluble Taxol Analogs

Promotion or inhibition of tubulin assembly into microtubules is the standard in vitro assay for evaluating potential antimicrotubule agents. Many agents to be tested are poorly soluble in aqueous solution and require a cosolvent such as DMSO4. However, DMSO itself can promote tubulin assembly, and...

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Detalhes bibliográficos
Main Authors: Sharma, Shubhada, Ganesh, Thota, Kingston, David G. I., Bane, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868410/
https://ncbi.nlm.nih.gov/pubmed/17097592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2006.10.01
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