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Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation
A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open-chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 wer...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225578/ https://ncbi.nlm.nih.gov/pubmed/22071526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.10.010 |
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