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Design, synthesis and biological evaluation of bridged epothilone D analogues†
Six epothilone D analogues with a bridge between the C4-methyl and the C12-methyl carbons were prepared in an attempt to constrain epothilone D to its proposed tubulin-binding conformation. Ring-closing metathesis (RCM) was employed as the key step to build the C4-C26 bridge. In antiproliferative as...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790820/ https://ncbi.nlm.nih.gov/pubmed/19039362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b814823f |
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