Novel Epothilone Lactones by an Unusual Diversion of the Grubbs’ Metathesis Reaction
An unusual reaction with Grubbs’ catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have comparable activities to epothilone D.
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930754/ https://ncbi.nlm.nih.gov/pubmed/20221478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b926174e |
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