Novel Epothilone Lactones by an Unusual Diversion of the Grubbs’ Metathesis Reaction

An unusual reaction with Grubbs’ catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have comparable activities to epothilone D.

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Detalhes bibliográficos
Main Authors: Chen, Qiao-Hong, Ganesh, Thota, Jiang, Yi, Banerjee, Abhijit, Sharma, Shubhada, Bane, Susan, Snyder, James P., Kingston, David G. I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930754/
https://ncbi.nlm.nih.gov/pubmed/20221478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b926174e
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2930754/
https://ncbi.nlm.nih.gov/pubmed/20221478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b926174e