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C6 –C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle
A series of conformationally restrained epothilone analogs with a short bridge between the methyl groups at C6 and C8 was designed to mimic the binding pose assigned to our recently reported EpoA-microtubule binding model. A versatile synthetic route to these bridged epothilone analogs has been succ...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248799/ https://ncbi.nlm.nih.gov/pubmed/22127984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201102630 |
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