Llwytho...

Bridging Converts a Noncytotoxic nor-Paclitaxel Derivative to a Cytotoxic Analog by Constraining it to the T-Taxol Conformation

The synthesis of the bridged A-nor-paclitaxel 4 has been achieved from paclitaxel in a key test of the T-Taxol conformational hypothesis. Although the unbridged A-nor-paclitaxel 3 is essentially non-cytotoxic, the bridged analog 4 is strongly cytotoxic. This result provides strong evidence for the T...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tang, Shoubin, Yang, Chao, Brodie, Peggy, Bane, Susan, Ravindra, Rudravajhala, Sharma, Shubhada, Jiang, Yi, Snyder, James P., Kingston, David G. I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562586/
https://ncbi.nlm.nih.gov/pubmed/16928054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol061438s
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