Bridging Converts a Noncytotoxic nor-Paclitaxel Derivative to a Cytotoxic Analog by Constraining it to the T-Taxol Conformation

The synthesis of the bridged A-nor-paclitaxel 4 has been achieved from paclitaxel in a key test of the T-Taxol conformational hypothesis. Although the unbridged A-nor-paclitaxel 3 is essentially non-cytotoxic, the bridged analog 4 is strongly cytotoxic. This result provides strong evidence for the T...

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Detalhes bibliográficos
Main Authors: Tang, Shoubin, Yang, Chao, Brodie, Peggy, Bane, Susan, Ravindra, Rudravajhala, Sharma, Shubhada, Jiang, Yi, Snyder, James P., Kingston, David G. I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562586/
https://ncbi.nlm.nih.gov/pubmed/16928054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol061438s
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