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The bioactive Taxol conformation on β-tubulin: Experimental evidence from highly active constrained analogs

The important anticancer drug Taxol (paclitaxel) binds to tubulin in a stoichiometric ratio and promotes its assembly into microtubules. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been made. In this work we present experimental and...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ganesh, Thota, Guza, Rebecca C., Bane, Susan, Ravindra, Rudravajhala, Shanker, Natasha, Lakdawala, Ami S., Snyder, James P., Kingston, David G. I.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC454156/
https://ncbi.nlm.nih.gov/pubmed/15226503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403459101
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