REDOR NMR Distance Measurements for the Tubulin-Bound Paclitaxel Conformation

The important anticancer drug Taxol(®) (paclitaxel, PTX) owes its unique activity to its ability to bind to tubulin in a stoichiometric ratio and promote its assembly into microtubules. The conformation of the microtubule-bound drug has been the focus of numerous research efforts, since the inabilit...

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Detalhes bibliográficos
Main Authors: Paik, Younkee, Yang, Chao, Metaferia, Belhu, Tang, Shoubin, Bane, Susan, Ravindra, Rudravajhala, Shanker, Natasha, Alcaraz, Ana A, Johnson, Scott A., Schaefer, Jacob, O'Connor, Robert D., Cegelski, Lynette, Snyder, James P., Kingston, David G. I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432525/
https://ncbi.nlm.nih.gov/pubmed/17212416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0656604
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