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Design and Synthesis of C6–C8 Bridged Epothilone A
[Image: see text] A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC(50) = 8.5 µM) against the A2780 human ovarian cancer cell line.
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249659/ https://ncbi.nlm.nih.gov/pubmed/18355076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol800422q |
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