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Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues

The synthesis of two deoxygenated analogues of potent epothilones is reported in an effort to analyze the relative importance of molecular conformation and ligand–target interactions to biological activity. 7-deoxy-epothilone D and 7-deoxy-(S)-14-methoxy-epothilone D were prepared through total synt...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Woods, Laura M., Arico, Joseph W., Frein, Jeffrey D., Sackett, Dan L., Taylor, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372660/
https://ncbi.nlm.nih.gov/pubmed/28304361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18030648
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